A native of Ohio, Nancy began her college career in design at the University of Cincinnati in industrial design. After two years of study, she was accepted as one of a few undergraduate students at Cranbrook Academy of Art where she completed her BFA in interdisciplinary design, and then went directly to graduate school at Yale University School of Art and received an MFA in graphic design. Within a year of graduation, she started a practice with her husband, photographer/designer Tom Wedell, whom she met at Cranbrook.
Their early projects developed a visual vocabulary with a complexity of structure and colour that reflected the high-technology and consumer electronics clients they had in Boston such as Digital Equipment Corporation, and Boston Acoustics. In 1983 Nancy won an Award in Progressive Architecture’s Conceptual Furniture Competition and in the late 1980s Skolos-Wedell’s work was featured in the book New American Design. Nancy began teaching in the late 1980s. Nancy was named a Boston AIGA fellow in 2003, and has won many awards with her husband including Silver Prize in Toyama (1985) and Bronze Prize in Lahti (1988) and Gold Prize in Warsaw (2010). She is currently the Dean of Architecture and Design at the RISD, Providence.